Entropy reduction via simplified image contourization

The process of contourization is presented which converts a raster image into a set of plateaux or contours. These contours can be grouped into a hierarchical structure, defining total spatial inclusion, called a contour tree. A contour coder has been developed which fully describes these contours in a compact and efficient manner and is the basis for an image compression method. Simplification of the contour tree has been undertaken by merging contour tree nodes thus lowering the contour tree's entropy. This can be exploited by the contour coder to increase the image compression ratio. By applying general and simple rules derived from physiological experiments on the human vision system, lossy image compression can be achieved which minimizes noticeable artifacts in the simplified image

Cost benefit analysis vs. referenda

We consider a planner who chooses between two possible public policies and ask whether a referendum or a cost benefit analysis leads to higher welfare. We find that a referendum leads to higher welfare than a cost benefit analyses in "common value" environments. Cost benefit analysis is better in "private value" environments.Cost benefit analysis, elections, referenda, project evaluation

Hyperspectral colon tissue cell classification

A novel algorithm to discriminate between normal and malignant tissue cells of the human colon is presented. The microscopic level images of human colon tissue cells were acquired using hyperspectral imaging technology at contiguous wavelength intervals of visible light. While hyperspectral imagery data provides a wealth of information, its large size normally means high computational processing complexity. Several methods exist to avoid the so-called curse of dimensionality and hence reduce the computational complexity. In this study, we experimented with Principal Component Analysis (PCA) and two modifications of Independent Component Analysis (ICA). In the first stage of the algorithm, the extracted components are used to separate four constituent parts of the colon tissue: nuclei, cytoplasm, lamina propria, and lumen. The segmentation is performed in an unsupervised fashion using the nearest centroid clustering algorithm. The segmented image is further used, in the second stage of the classification algorithm, to exploit the spatial relationship between the labeled constituent parts. Experimental results using supervised Support Vector Machines (SVM) classification based on multiscale morphological features reveal the discrimination between normal and malignant tissue cells with a reasonable degree of accuracy

“Don’t Be Stupid, Stupid!” Cognitive-Behavioral Techniques to Reduce Irrational Beliefs and Enhance Focus in a Youth Tennis Player

This case reports the intervention approach the first author adopted while working with a youth tennis player. The athlete held irrational beliefs and was struggling to maintain emotional control. The neophyte sport psychology practitioner adopted a cognitive-behavioral approach to practice. The intervention focused on (a) using rational emotive behavior therapy (REBT) to replace unhelpful beliefs about unforced errors with a new rational philosophy and (b) using a distraction-control plan to restructure the player’s thoughts and beliefs in relation to opponents’ perceived gamesmanship. Intervention effectiveness was evaluated through qualitative data from the athlete and his parents and the reflections of the practitioner. Feedback suggests that REBT and distraction-control plans can be effective in helping youth athletes manage their thought patterns and improve emotional control during competition. This case also demonstrates the importance of practitioners’ having a flexible and adaptable approach to practice—one that meets individual client needs

The genomic basis of cichlid fish adaptation within the deepwater “twilight zone” of Lake Malawi

Deepwater environments are characterized by low levels of available light at narrow spectra, great hydrostatic pressure, and low levels of dissolved oxygen—conditions predicted to exert highly specific selection pressures. In Lake Malawi over 800 cichlid species have evolved, and this adaptive radiation extends into the “twilight zone” below 50 m. We use population-level RAD-seq data to investigate whether four endemic deepwater species (Diplotaxodon spp.) have experienced divergent selection within this environment. We identify candidate genes including regulators of photoreceptor function, photopigments, lens morphology, and haemoglobin, many not previously implicated in cichlid adaptive radiations. Colocalization of functionally linked genes suggests coadapted “supergene” complexes. Comparisons of Diplotaxodon to the broader Lake Malawi radiation using genome resequencing data revealed functional substitutions and signatures of positive selection in candidate genes. Our data provide unique insights into genomic adaptation within deepwater habitats, and suggest genome-level specialization for life at depth as an important process in cichlid radiation

High Temporal Resolution XMM Monitoring of PKS 2155-304

The bright, strongly variable BL Lac object PKS 2155-304 was observed by XMM for two essentially uninterrupted periods of ~11 and 16 hr on 30-31 May 2000. The strongest variations occurred in the highest energy bands. After scaling for this effect, the three softest bands (0.1-1.7 keV) showed strong correlation with no measurable lag to reliable limits of \tau \ls 0.3 hr. However, the hardest band (~3 keV) was less well-correlated with the other three, especially on short time scales, showing deviations of ~10-20% in ~1 hr although, again, no significant interband lag was detected. This result and examination of previous ASCA and BeppoSAX cross-correlation functions suggest that previous claims of soft lags on time scales of 0.3-4 hr could well be an artifact of periodic interruptions due to Earth-occultation every 1.6 hr. Previous determinations of the magnetic field/bulk Lorentz factor were therefore premature, as these data provide only a lower limit of B \gamma^{1/3} \gs 2.5 G. The hardest band encompasses the spectral region above the high-energy break; its enhanced variability could be indicating that the break energy of the synchrotron spectrum, and therefore of the underlying electron energy distribution, changes independently of the lower energies.Comment: 13 pages, 3 figures, accepted by Ap

Timing of Substorm-Associated Auroral Oscillations

Previous studies have shown that auroral luminosity oscillations are often associated with substorms. Here we examine photometer data for the magnetospheric substorm on April 1, 2000 (expansive phase onset at 0525 UT) to study the detailed timing of the auroral oscillations relative to onset. Accurate timing information for the periodicities in the photometer data were determined using the wavelet transform. We find that the oscillations occur primarily during the recovery phase. Copyright © The Society of Geomagnetism and Eart

Milk whey protein concentration and mRNA associated with β-lactoglobulin phenotype

Two common genetic variants of β-lactoglobulin (β-lg), A and B, exist as co- dominant alleles in dairy cattle (Aschaffenburg, 1968). Numerous studies have shown that cows homozygous for β-lg A have more β-lg and less α-lactalbumin (α-la) and casein in their milk than cows expressing only the B variant of β-lg (Ng-Kwai-Hang et al. 1987; Graml et al. 1989; Hill, 1993; Hill et al. 1995, 1997). These differences have a significant impact on the processing characteristics of the milk. For instance, the moisture-adjusted yield of Cheddar cheese is up to 10% higher using milk from cows of the β-lg BB phenotype compared with milk from cows expressing only the A variant (Hill et al. 1997). All these studies, however, describe compositional differences associated with β-lg phenotype in established lactation only. No information is available on the first few weeks of lactation, when there are marked changes in the concentrations of β-lg and α-la (Pérez et al. 1990)

Inflationary Cosmological Perturbations of Quantum-Mechanical Origin

This review article aims at presenting the theory of inflation. We first describe the background spacetime behavior during the slow-roll phase and analyze how inflation ends and the Universe reheats. Then, we present the theory of cosmological perturbations with special emphasis on their behavior during inflation. In particular, we discuss the quantum-mechanical nature of the fluctuations and show how the uncertainty principle fixes the amplitude of the perturbations. In a next step, we calculate the inflationary power spectra in the slow-roll approximation and compare these theoretical predictions to the recent high accuracy measurements of the Cosmic Microwave Background radiation (CMBR) anisotropy. We show how these data already constrain the underlying inflationary high energy physics. Finally, we conclude with some speculations about the trans-Planckian problem, arguing that this issue could allow us to open a window on physical phenomena which have never been probed so far.Comment: Review Article, 47 pages, 3 figures. Lectures given at the 40th Karpacz Winter School on Theoretical Physics (Poland, Feb. 2004), submitted to Lecture Notes in Physic

Combination interventions to prevent HCV transmission among people who inject drugs: modelling the impact of antiviral treatment, needle and syringe programs, and opiate substitution therapy

BackgroundInterventions such as opiate substitution therapy (OST) and high-coverage needle and syringe programs (HCNSP) cannot substantially reduce hepatitis C virus (HCV) prevalence among people who inject drugs (PWID). HCV antiviral treatment may prevent onward transmission. We project the impact of combining OST, HCNSP, and antiviral treatment on HCV prevalence/incidence among PWID.MethodsAn HCV transmission model among PWID was used to project the combinations of OST, HCNSP, and antiviral treatment required to achieve different prevalence and incidence reductions within 10 years for 3 chronic prevalence scenarios and the impact of HCV treatment if only delivered through OST programs. Multivariate and univariate sensitivity analyses were performed.ResultsLarge reductions (>45%) in HCV chronic prevalence over 10 years require HCV antiviral treatment. Scaling up OST and HCNSP substantially reduces the treatment rate required to achieve specific HCV prevalence reductions. If OST and HCNSP coverage were increased to 40% each (no coverage at baseline), then annually treating 10, 23, or 42 per 1000 PWID over 10 years would halve prevalence for 20%, 40%, or 60% baseline chronic HCV prevalences, respectively. Approximately 30% fewer treatments are necessary with new direct-acting antivirals. If coverage of OST and HCNSP is 50% at baseline, similar prevalence reductions require higher treatment rates for the same OST and HCNSP coverage.ConclusionsCombining antiviral treatment with OST with HCNSP is critical for achieving substantial reductions (>50%) in HCV chronic prevalence over 10 years. Empirical studies are required on how best to scale up antiviral treatment and combine treatment with other interventions